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Literature summary extracted from
- Human Hageman factor and its fragments (1988), Methods Enzymol., 163, 68-80.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.38 | Ala-Phe-Arg-chloromethylketone | - |
Homo sapiens |  |
| 3.4.21.38 | antithrombin III | - |
Homo sapiens | |
| 3.4.21.38 | C1 esterase inhibitor | - |
Homo sapiens | |
| 3.4.21.38 | dansyl-Glu-Gly-Arg-chloromethylketone | - |
Homo sapiens | |
| 3.4.21.38 | Phe-Phe-Arg-chloromethylketone | - |
Homo sapiens | |
| 3.4.21.38 | Phe-Pro-Arg-chloromethylketone | - |
Homo sapiens | |
| 3.4.21.38 | Pro-Phe-Arg chloromethylketone | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.38 | 0.018 | - |
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide | - |
Homo sapiens | |
| 3.4.21.38 | 0.021 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 8.0 | Homo sapiens | |
| 3.4.21.38 | 0.054 | - |
Pro-Phe-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
| 3.4.21.38 | 0.19 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 7.8, 0.117 M NaCl | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.38 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.38 | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.38 | D-Pro-Phe-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.38 | Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg + 4-nitroaniline | - |
? | |
| 3.4.21.38 | Nalpha-benzoyl-Ile-Glu-OCH-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.38 | Nalpha-benzoyl-Ile-Glu-OH-Gly-Arg-4-nitroanilide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.38 | Pro-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.38 | 1.9 | - |
Pro-Phe-Arg-4-methylcoumarin 7-amide | - |
Homo sapiens | |
| 3.4.21.38 | 14 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 8.0 | Homo sapiens | |
| 3.4.21.38 | 15 | - |
D-Pro-Phe-Arg-4-nitroanilide | 0.05 M Tris-HCl, pH 7.8, 0.117 M NaCl | Homo sapiens | |
| 3.4.21.38 | 23 | - |
Nalpha-benzoyl-Ile-Glu(-OR)-Gly-Arg-4-nitroanilide | - |
Homo sapiens | |
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